1000KG Urolithin A Urolithin Powder Urolithin B Factory Supply In Stock
1000KG Urolithin A Urolithin Powder Urolithin B Factory Supply In Stock
Wisepowder have the capability to produce and supply large quantity of Urolithin powder series, include Urolithin A, Urolithin B, Urolithin C...All Urolithin powder production under cGMP condition and strict quality control system, all testing documents and sample available. Full in stock, monthly production capacity more than 800KG-1000KG.Welcome inquiry and discuss cooperation.
Urolithin A Powder CAS 1143-70-0
Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis. Urolithin A is not known to be found in any food source. Its bioavailability mostly depends on individual microbiota composition, as only some bacteria are able to convert ellagitannins into urolithins.
Manufacture: Batch Production
Package: 1KG/bag, 25KG/drum
Urolithin A powder Base Information
Name Urolithin A Powder
CAS 1143-70-0
Purity 98%
Chemical name 3,8-Dihydroxybenzo[c]chromen-6-one
Synonyms 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one; 3,8-DIHYDROXYDIBENZO-(B,D)PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo[c]chromen-6-one; Castoreum pigment I; Urolithin A; 6H-Dibenzo(B,D)pyran-6-one, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-one); urolithin-A(UA;3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
Molecular Formula C13H8O4
Molecular Weight 228.2
Melting Point >300 °C
InChI Key RIUPLDUFZCXCHM-UHFFFAOYSA-N
Form solid
Appearance Light Yellow powder
Half Life /
Solubility Soluble in DMSO (3 mg/mL).
Storage Condition Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Application Urolithin A is a metabolite of ellagitannin; Pharmaceutical Intermediates
Testing Document Coa, MSDS, HPLC..
Testing Sammple available
Urolithin A Sample
Urolithin A Powder General Description
Urolithin A powder is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria and is an inducer of mitophagy. Urolithin A shifts mitochondria from CI- to CII-driven respiration, extends lifespan and improves muscle function. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones. Its precursors – ellagic acids and ellagitannins – are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Since the 2000s, urolithin A has been subject of preliminary studies regarding its possible biological effects.
Urolithin A powder can improve the quality and function of mitochondria, and increase the strength and endurance of aging muscles. It is the only natural product that has been proven to restart mitochondrial autophagy and reverse muscle aging.
Urolithins are microflora human metabolites of dietary ellagic acid derivatives，such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine.
During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans. Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice.
Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites.
Urolithins are found in plasma mostly as glucuronides at low concentrations.
Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella
Urolithin A powder History
In laboratory studies, urolithin A powder was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging.[14] This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).
Urolithin A powder Application
Urolithin A powder is intended for use as an ingredient in select foods or for special dietary uses in meal replacement products based on its nutritive activity in supporting general mitochondrial health.
Urolithin A powder More research
Urolithin A is not known to be found in any food. It forms as the result of transformation of ellagic acids and ellagitannins by the gut microflora in humans. Ellagic acid itself results from the hydrolysis of ellagitannins in the gut in the presence of water.[citation needed]
Sources of ellagitannins are: pomegranates, nuts, some berries (raspberries, strawberries, blackberries, cloudberries), tea, muscadine grapes, many tropical fruits, and oak-aged wines (table below).
The conversion of the ellagic acids into urolithin A depends on individual microflora composition and can vary significantly.
Urolithin B powder CAS 1139-83-9
Urolithin B is a natural metabolite of ellagitannin present in pomegranates and other fruits and nuts. Recognized by scientists as an anti-aging drug, oral administration can restore mitochondria and reverse muscle aging, and is a potent intestinal metabolite.
Manufacture: Batch Production
Package: 1KG/bag, 25KG/drum
Urolithin B powder base information
Name Urolithin B Powder
CAS 1139-83-9
Purity 98%
Chemical name 3-Hydroxy-6H-dibenzo[b,d]pyran-6-one
Synonyms AURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo[c]chromenone;3-hydroxybenzo[c]chromen-6-one; 3-Hydroxy-benzo[c]chromen-6-one; 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE; 6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-;3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR
Molecular Formula C13H8O3
Molecular Weight 212.2 g/mol
Melting Point 247 °C
InChI Key WXUQMTRHPNOXBV-UHFFFAOYSA-N
Form Solid
Appearance Light brown powder
Half Life /
Solubility soluble5mg/mL, clear (warmed)
Storage Condition 2-8°C
Application Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity.
Testing Document Coa,MSDS,HPLC…etc
Urolithin B sample: available
Urolithin B powder General Description
Urolithin B is an urolithin, a type of phenolic compounds produced in the human gut after absorption of ellagitannins-containing food such as pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine. Urolithin B is found in the urine in the form of urolithin B glucuronide.
Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass. Urolithin B can also display estrogenic and/or anti-estrogenic activity.
Urolithin B powder History
Urolithin B can be used as an drug for antitumor and anticancer. Urolithin B( CAS NO :1139-83-9) is an urolithin ,it is also produced in the human gut after absorption of ellagitannins from pomegranate. Urolithin B can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet.
Urolithin B powder is also an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity. It has anti-inflammatory and antioxidant effects. Urolithin B is also used be a regulator of skeletal muscle mass.
And Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.
Urolithin B powder More research
Urolithin B can mitigate muscle damage experienced during intense exercise and protect muscle against stresses induced by a high-fat diet. Clinical research on Urolithin B in mice found that it enhanced myotubes growth and differentiation by increasing protein synthesis. It demonstrated an ability to inhibit the ubiquitin–proteasome pathway (UPP), the principal mechanism for protein catabolism. It also induced muscle hypertrophy and reduced muscle atrophy.
When compared to testosterone, Urolithin B when taken at 15 uM increased androgen receptor activity by 90% while testosterone was only able to accomplish increased receptor activity of 50% at 100uM. This means that it takes a lot less Urolithin B to increase androgen activity more effectively then the higher amount of testosteronewhich increases androgen activity less effectively.
Moreover, most effective 15uM of Urolithin B larger muscle protein synthesis via 96% when in comparison to 100uM of insulin, which larger muscle protein synthesis via most effective 61%. The belief is that it takes a long way much less Urolithin B to extend muscle protein synthesis with a lot upper degree of effectiveness.
This studies show that Urolithin B can inhibit protein catabolism while simultaneously increase protein synthesis, it is a natural ingredient that helps to build lean muscle while preventing muscle breakdown.
Comments
Post a Comment